Human Intestinal Ischemia-Reperfusion–Induced Inflammation Characterized

Intestinal ischemia.

Ischemic injury to the gastrointestinal tract can threaten bowel viability with potential catastrophic consequences, including intestinal necrosis and gangrene. The presenting symptoms and signs are relatively nonspecific and diagnosis requires a high index of clinical suspicion. AMI often results from an embolus or thrombus within the SMA, although a low-flow state through an area of profound ...

Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury.

Acute renal failure (ARF) commonly occurs after whole body ischemia. Most experimental models of ARF have relied on the isolated renal artery clamping model; however, there is a pressing need to develop and understand the pathogenesis of new models with more "clinical relevance." We evaluated a new murine model of ARF after whole body ischemia reperfusion injury (WBIRI). WBIRI was induced by an...

Intestinal Ischemia and Gangrene

1.1 Historical background Antonio Beniviene was the first to describe mesenteric ischemia as early as the 15th century. It was not before the mid 19th century during which the entity was extensively reported and researched after case reports by Virchow and others. The first successful surgical treatment of acute mesenteric ischmia (AMI) was performed by Elliot, who, in 1895, performed a resecti...

Human-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation.

Lactobacillus reuteri (L. reuteri) is a probiotic that inhibits the severity of enteric infections and modulates the immune system. Human-derived L. reuteri strains DSM17938, ATCC PTA4659, ATCC PTA 5289, and ATCC PTA 6475 have demonstrated strain-specific immunomodulation in cultured monocytoid cells, but information about how these strains affect inflammation in intestinal epithelium is limite...

Damage and Inflammation Intestinal Ischemia/Reperfusion-Induced TLR2 Modulates Antibodies Required for